Quantitative measurement of skin perfusion with xenon-133
Quantitative assessment of skin perfusion has value in both medical and surgical therapeutic decision-making. We have adapted a technique using intradermal xenon-133 dissolved in saline for use with a gamma camera interfaced to a minicomputer. It allows rapid evaluation of several sites simultaneously. The monoexponential washout rate of the injected tracer during the first 6 min is entered into the Schmidt-Kety equation to provide blood-flow rates in ml/min per 100 g. Reproducibility of the method in normal subjects is satisfactory. An important experimental variable is ambient temperature, since perfusion rates in normal limbs at low temperatures can approach those levels found in ischemic limbs. The intradermal technique has practical advantages over other methods for study of limb or skin perfusion.
- Research Organization:
- Veterans Administration Medical Center, Tucson, AZ
- OSTI ID:
- 5264877
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:2; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMBIENT TEMPERATURE
ANEMIAS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
COMPUTER CALCULATIONS
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HEMIC DISEASES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISCHEMIA
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
NUMERICAL DATA
ORGANS
PATIENTS
PERFUSED TISSUES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
SCINTISCANNING
SKIN
SKIN ABSORPTION
SYMPTOMS
TEMPERATURE EFFECTS
TIME DEPENDENCE
TISSUES
UPTAKE
USES
XENON 133
XENON ISOTOPES