Preoperative imaging in primary hyperparathyroidism. Role of thallium-technetium subtraction scintigraphy

Journal Article · Sun Oct 01 00:00:00 EDT 1989 · Archives of Otolaryngology Head and Neck Surgery; (USA)

DOI:https://doi.org/10.1001/archotol.1989.01860340051016· OSTI ID:5262212

Foster, G S; Bekerman, C; Blend, M J; Byrom, E; Pinsky, S M ^[1]

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1. Michael Reese Hospital and Medical Center, Chicago, IL (USA)

Primary hyperparathyroidism, although often silent clinically, may lead to significant morbidity if it remains untreated. In more than 95% of all cases the cause is a parathyroid adenoma or glandular hyperplasia. Regression of disease follows successful surgical excision of the abnormal parathyroid gland. Recurrent or persistent hyperparathyroidism is most commonly caused by solitary adenomas, which may have an ectopic location. Preoperative localization of lesions may improve postoperative cure rates and decrease morbidity. Thallium T1 201 chloride-technetium Tc 99m pertechnetate subtraction scintigraphy was performed on 15 patients with primary hyperparathyroidism. The sensitivity and specificity for detection of abnormal glands were 90% and 95%, respectively. False-positive or false-negative results were minimize by strict adherence to a protocol and by the use of well-defined diagnostic criteria. Because of the superior sensitivity and specificity, this modality should be the primary imaging method of choice for preoperative evaluation of primary hyperparathyroidism. The relative role of other imaging modalities is also discussed. 31 references.

• OSTI ID: 5262212
• Journal Information: Archives of Otolaryngology Head and Neck Surgery; (USA), Journal Name: Archives of Otolaryngology Head and Neck Surgery; (USA) Vol. 115:10; ISSN 0886-4470; ISSN AONSE
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOMAS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOCUMENT TYPES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
HYPERPARATHYROIDISM
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PARATHYROID GLANDS
PERTECHNETATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
REFRACTORY METAL COMPOUNDS
REVIEWS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SENSITIVITY ANALYSIS
SPECIFICITY
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES