Quantitative iodine-123 IMP imaging of brain perfusion in schizophrenia

Journal Article · Sun Oct 01 00:00:00 EDT 1989 · Journal of Nuclear Medicine; (USA)

OSTI ID:5262073

Cohen, M B; Lake, R R; Graham, L S; King, M A; Kling, A S; Fitten, L J; O'Rear, J; Bronca, G A; Gan, M; Servrin, R ^[1]

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1. Nuclear Medicine Service, Sepulveda, CA (USA)

Decreased perfusion in the frontal lobes of patients with chronic schizophrenia has been reported by multiple observes using a variety of techniques. Other observers have been unable to confirm this finding using similar techniques. In this study quantitative single photon emission computed tomography brain imaging was performed using p,5n ({sup 123}I)IMP in five normal subjects and ten chronically medicated patients with schizophrenia. The acquisition data were preprocessed with an image dependent Metz filter and reconstructed using a ramp filtered back projection technique. The uptake in each of 50 regions of interest in each subject was normalized to the uptake in the cerebellum. There were no significant confirmed differences in the comparable ratios of normal subjects and patients with schizophrenia even at the p = 0.15 level. Hypofrontality was not observed.

• OSTI ID: 5262073
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 30:10; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
NERVOUS SYSTEM DISEASES
DIAGNOSIS
BLOOD FLOW
IODINE 123
PATIENTS
PERFUSED ORGANS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics