Effects of lead on delta-aminolevulinic acid dehydratase activity, growth, hemoglobin content, and reproduction in Daphnia magna

Journal Article · Mon Apr 01 04:00:00 EST 1985 · Ecotoxicol. Environ. Saf.; (United States)

DOI:https://doi.org/10.1016/0147-6513(85)90024-7· OSTI ID:5261986

Berglind, R; Dave, G; Sjoebeck, M L

The effects of continuous exposure to lead for various periods and recovery in clean water on delta-aminolevulinic acid dehydratase (ALA-D) activity, hemoglobin content, growth, and reproduction were studied in Daphnia magna. Steady-state inhibition of ALA-D activity was reached within 2 days in 16, 64, and 256 micrograms Pb liter-1, but restoration in clean water was prolonged in relation to previous exposure. In spite of the inhibition of ALA-D activity hemoglobin content increased after 2 days in 16 and 24 micrograms Pb liter-1. Furthermore, hemoglobin content in previously exposed animals increased during recovery in clean water. Maximum hemoglobin content (2.9 times control value) was found after 2 days recovery of animals exposed to 64 micrograms Pb liter-1. These findings suggest that some enzyme(s) other than ALA-D in the biosynthetic pathway of hemoglobin formation is (are) more sensitive to lead. Growth, in contrast to reproduction, was stimulated by low concentrations of lead (less than 64 micrograms Pb liter-1), although in 256 micrograms Pb liter-1 growth was also significantly impaired. After 19 days the 16 and 50% reproductive impairment concentrations were less than or equal to 1 and 10 micrograms Pb liter-1, respectively.

• Research Organization: Univ. of Goeteborg, Sweden
• OSTI ID: 5261986
• Journal Information: Ecotoxicol. Environ. Saf.; (United States), Journal Name: Ecotoxicol. Environ. Saf.; (United States) Vol. 2; ISSN EESAD
• Country of Publication: United States
• Language: English

Related Subjects

560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
AMINOLEVULINIC ACID
ANIMALS
AQUATIC ORGANISMS
ARTHROPODS
BIOLOGICAL EFFECTS
BRANCHIOPODS
CARBON-OXYGEN LYASES
CARBOXYLIC ACIDS
CHRONIC EXPOSURE
CRUSTACEANS
DAPHNIA
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GLOBIN
GROWTH
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDRO-LYASES
HYDROGEN COMPOUNDS
INVERTEBRATES
LEAD
LYASES
METALS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN
OXYGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
REPRODUCTION
SEAWATER
WATER