Nonsurgical treatment of aggressive fibromatosis in the head and neck

Journal Article · Fri Sep 01 04:00:00 EDT 1989 · Otolaryngology and Head and Neck Surgery; (USA)

OSTI ID:5260364

West, Jr, C B; Shagets, F W; Mansfield, M J ^[1]

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1. Wilford Hall USAF Medical Center, Lackland Air Force Base, TX (USA)

Aggressive fibromatosis is a poorly defined, locally aggressive, yet histologically benign fibroblastic proliferative lesion that may occur in the head and neck. The lesion is highly cellular and locally infiltrative and has a propensity to invade and erode bone, compromising vital structures within the head and neck. However, it is not a true malignancy because it does not have malignant cytologic characteristics nor does it metastasize. We present two cases of aggressive fibromatosis occurring in young adult men. The first case involved a rapidly enlarging mass of the anterior maxilla that involved the upper lip, nasal alae, nasal septum, inferior turbinates, and hard palate. The patient underwent incisional biopsy to confirm the diagnosis. Because of difficulty in determining the actual margins of this extensive lesion and the significant morbidity that would have resulted from surgical resection, we elected to treat this patient with chemotherapy and radiation therapy. The second case was an extensive lesion involving the right temporal bone, pterygomaxillary space, and infratemporal, temporal, and middle cranial fossae. Incisional biopsy confirmed the diagnosis. Because of the lack of functional and cosmetic deficits and the unavoidable morbidity of a surgical resection, this patient was treated with radiation therapy. Although wide field resection is the most satisfactory form of treatment, in situations in which this modality would result in unacceptable morbidity or if surgical margins are positive, then radiation therapy and chemotherapy should be considered. Support for these therapeutic modalities is found in larger series of cases outside the head and neck.

• OSTI ID: 5260364
• Journal Information: Otolaryngology and Head and Neck Surgery; (USA), Journal Name: Otolaryngology and Head and Neck Surgery; (USA) Vol. 101:3; ISSN 0194-5998; ISSN OHNSD
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANTINEOPLASTIC DRUGS
BODY
BODY AREAS
CELL PROLIFERATION
CHEMOTHERAPY
COBALT ISOTOPES
COMBINED THERAPY
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
FIBROBLASTS
HEAD
ISOTOPES
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIOLOGY
RADIOTHERAPY
SOMATIC CELLS
THERAPY