A broader perspective of sexual differentiation
Journal Article
·
· American Journal of Medical Genetics
- DePaul Univ., Chicago, IL (United States)
- Northwestern Univ. Medical School, Chicago, IL (United States)
Human sexual differentiation is customarily depicted as a series of embryonic events that lead to male and female gonadal development and differential hormone expression that have behavioral as well as biological outcomes. The salient components of these events are the differential expression of two hormones - testosterone and Muellerian inhibiting substance - and the SRY gene, regulating, in turn, the transcription of other genes and culminating in male differentiation. Sex determination, then, is generally described as initially proceeding down a path toward female development unless the bipotential, indifferent gonad is modified toward male development by genes on the Y chromosome. 28 refs.
- OSTI ID:
- 525997
- Journal Information:
- American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 3 Vol. 69; ISSN 0148-7299; ISSN AJMGDA
- Country of Publication:
- United States
- Language:
- English
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