Physiological pharmacokinetic modeling

Journal Article · Thu Oct 01 00:00:00 EDT 1987 · Environ. Sci. Technol.; (United States)

DOI:https://doi.org/10.1021/es50001a004· OSTI ID:5252878

Menzel, D B

Risk assessment often defines the approach and the degree of regulation, decisions in risk assessment often have major regulatory impacts. Chemicals that have economic value or that were byproducts of the chemical industry are common subjects of such decisions. Regrettably, decisions related to risk assessment, science, or regulatory matters will frequently be made with incomplete information and on the basis of intuitive reasoning. Statistical fits to experimental data have been used to estimate risks in humans from experimental data in animals. These treatments have not taken into account the obvious differences in physiology, biochemistry, and size between aniamals and humans. In this article the use of mathematical models based on continuous relationships, rather than quantal events, are discussed. The mathematical models can be used to adjust the dose in the quantal response model, but the emphasis will be on how these mathematical models are conceived and what implications their use holds for risk assessment. Experiments with humans that produce toxic effects cannot be done. Data for human toxicity will always be lacking.

• Research Organization: Duke Comprehensive Cancer Center, Durham, NC (USA)
• OSTI ID: 5252878
• Journal Information: Environ. Sci. Technol.; (United States), Vol. 21:10
• Country of Publication: United States
• Language: English

Related Subjects

29 ENERGY PLANNING
POLICY AND ECONOMY
CARCINOGENS
BIOLOGICAL EFFECTS
DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
MAN
INJURIES
USES
TOXIC MATERIALS
AIR POLLUTION
EXPERIMENTAL DATA
NEOPLASMS
RISK ASSESSMENT
ANIMALS
DATA
DISEASES
INFORMATION
MAMMALS
MATERIALS
NUMERICAL DATA
POLLUTION
PRIMATES
VERTEBRATES
290300* - Energy Planning & Policy- Environment
Health
& Safety