Prolonged bone marrow and skin allograft survival after pretransplant conditioning with cyclophosphamide and total lymphoid irradiation. [Mice]

Journal Article · Thu May 01 00:00:00 EDT 1980 · Transplantation; (United States)

OSTI ID:5246537

Kersey, J H; Kruger, J; Song, C; Kloster, B

Current studies were designed to provide long-term survival of allogeneic skin and bone marrow in mice preconditioned with various combinations of cyclophosphamide (CY) and/or total lymphoid irradiation (TLI). Long-term skin graft and bone marrow survival was obtained across the major histocompatibility barrier (BALB/c into C57BL/6) using pregrafting conditioning with either fractionated TLI or the combination of CY with a single dose of TLI. CY alone and a single dose of TLI alone were relatively ineffective as regrafting immunosuppressive combinations. Allogeneic bone marrow was required for long-term skin graft survival with either conditioning regimen. Allogeneic marrow transplantation resulted in somewhat more deaths than syngeneic transplantation with both CY + TLI and fractionated TLI.

• Research Organization: Univ. of Minnesota, Minneapolis
• OSTI ID: 5246537
• Journal Information: Transplantation; (United States), Vol. 29:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ENTERITIS
RADIOINDUCTION
GASTROINTESTINAL TRACT
BIOLOGICAL RADIATION EFFECTS
GRAFT-HOST REACTION
IMMUNOSUPPRESSION
LUNGS
LYMPHATIC SYSTEM
PNEUMONITIS
RADIOTHERAPY
SIDE EFFECTS
BONE MARROW
DOSE-RESPONSE RELATIONSHIPS
ENDOXAN
FRACTIONATED IRRADIATION
GRAFTS
MICE
PARTIAL BODY IRRADIATION
RADIATION DOSES
SKIN
TOLERANCE
WHOLE-BODY IRRADIATION
X RADIATION
ALKYLATING AGENTS
ANIMALS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RESPIRATORY SYSTEM
RODENTS
THERAPY
TISSUES
TRANSPLANTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)
551000 - Physiological Systems