Dosimetric implications of new compounds for neutron capture therapy (NCT)

Conference · Fri Jan 01 04:00:00 EST 1982

OSTI ID:5243650

Fairchild, R G

Systemic application of radiolabeled or cytotoxic agents should allow targeting of primary and metastatic neoplasms on a cellular level. In fact, drug uptake in non-target cell pools often exceeds toxic levels before sufficient amounts are delivered to tumor. In addition, at the large concentration of molecules necessary for therapy, effects of saturation are often found. Application of NCT can circumvent problems associated with high uptake in competing non-target cell pools, as the /sup 10/B(n,..cap alpha..)/sup 7/Li reaction is activated only within the radiation field. A comparison with other modes of particle therapy indicated that NCT provides significant advantages. It is however, difficult to obtain vehicles for boron transport which demonstrate both the tumor specificity and concentration requisite for NCT. A number of biomolecules have been investigated which show both the necessary concentration and specificity. These include chlorpromazine, thiouracil, porphyrins, amino acids, and nucleosides. However, these analogs have yet to be made available for NCT. Dosimetric implications of binding sites are considered, as well as alternate neutron sources. (ERB)

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5243650
• Report Number(s): BNL-31463; CONF-820666-4; ON: DE82017613
• Country of Publication: United States
• Language: English

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AMINO ACIDS
ANIMAL CELLS
ANTIMETABOLITES
ANTITHYROID DRUGS
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BARYON REACTIONS
BORON COMPOUNDS
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
DOSIMETRY
DRUGS
HADRON REACTIONS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONE ANTAGONISTS
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
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NEUTRON REACTIONS
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEON REACTIONS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
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ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOTHIAZINES
PORPHYRINS
PYRIMIDINES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RECEPTORS
RIBOSIDES
SYNTHESIS
THERAPY
THIOLS
THIOURACIL
TUMOR CELLS
URACILS