Possible parathyroid imaging using Ga-67 and other aluminum analogs. [Kinetics studies in rats]

Journal Article · Thu May 01 04:00:00 EDT 1980 · J. Nucl. Med.; (United States)

OSTI ID:5243544

Cann, C E; Prussin, S G

Aluminum has been found to localize in parathyroid adenomas, but it has no isotopes suitable for imaging. Chemical analogs of aluminum were therefore evaluated as potential parathyroid seekers. Uptakes of gallium-67, scandium-46, and lutetium-177 were measured in rat parathyroid, thyroid, cervical muscle, and whole blood, over the time period 30 min to 8 days. Both differential and absolute uptakes of Ga-67 and Sc-46 in the parathyroids are greater than that reported for Se-75 selenomethionine. Uptake of Ga-67 is about 2% of the injected dose per gram of parathyroid tissue at 3 to 4 days, with a parathyroid-to-thyroid uptake ratio of about 6. Studies indicate possible imaging of adenomas at least as small as those now detected only with invasive methods.

• Research Organization: Univ. of California, Berkeley
• OSTI ID: 5243544
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GALLIUM 67
GALLIUM ISOTOPES
GLANDS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUTETIUM 177
LUTETIUM ISOTOPES
MAMMALS
MATERIALS
MUSCLES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PARATHYROID GLANDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RATS
RODENTS
SCANDIUM 46
SCANDIUM ISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
THYROID
TISSUE DISTRIBUTION
VERTEBRATES