Tobacco constituents are mitogenic for arterial smooth-muscle cells

Journal Article · Mon Jul 01 00:00:00 EDT 1985 · Am. J. Pathol.; (United States)

OSTI ID:5242721

Becker, C G; Hajjar, D P; Hefton, J M

Tobacco glycoprotein (TGP) purified from flue-cured tobacco leaves, tar-derived material (TAR), the water soluble, nondialyzable, delipidized extract of cigarette smoke condensate, rutin-bovine serum albumin conjugates, quercetin, and chlorogenic acid are mitogenic for bovine aortic smooth-muscle cells, but not adventitial fibroblasts. The mitogenicity appears to depend on polyphenol epitopes on carrier molecules. Ellagic acid, another plant polyphenol, inhibited arterial smooth-muscle proliferation. These results suggest that a number of ubiquitous, plant-derived substances may influence smooth-muscle cell proliferation in the arterial wall.

• Research Organization: Cornell Univ. Medical College, New York, NY
• OSTI ID: 5242721
• Journal Information: Am. J. Pathol.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GLUCOPROTEINS
BIOLOGICAL EFFECTS
MUSCLES
CELL PROLIFERATION
PHENOLS
QUERCETIN
TAR
TOBACCO SMOKES
ANTIGENS
ARTERIES
CATTLE
FIBROBLASTS
IN VITRO
MITOGENS
POLYMERS
STRUCTURE-ACTIVITY RELATIONSHIPS
TOBACCO
AEROSOLS
ANIMAL CELLS
ANIMALS
AROMATICS
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
COLLOIDS
CONNECTIVE TISSUE CELLS
DISPERSIONS
DOMESTIC ANIMALS
FLAVENOIDS
FLAVONES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
POLYPHENOLS
PROTEINS
PYRANS
RESIDUES
RUMINANTS
SACCHARIDES
SMOKES
SOLS
SOMATIC CELLS
VERTEBRATES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)