2-hydroxyestradiol modifies serotonergic processes in the male rat brain
Thesis/Dissertation
·
OSTI ID:5241994
The effects of chronic (5 day) 2-hydroxyestradiol or estradiol on catecholaminergic and serotonergic neurons in the male rat brain were studied. The results indicate estrogen to be specific is inducing changes in dopaminergic systems; whereas its hydroxymetabolite appears to have a preference for serotonergic processes. In particular, in vitro 2-hydroxyestradiol appears to be a potent inhibitor of /sup 3/H-imipramine binding in brain; this inhibition is especially potent in the cortex, where it is equal in potency to serotonin. However, unlike serotonin, which is a competitive inhibitor of imipramine, 2-hydroxyestradiol is an uncompetitive inhibitor of /sup 3/H-imipramine binding in cortex and hypothalamus and a noncompetitive inhibitor in the striatum; this suggests that the inhibition of binding takes place at a point other than the site of serotonin uptake. In vitro 2-hydroxyestradiol also appears to increase the uptake of serotonin into these tissues, a change which would be expected if the imipramine binding is blocked.
- Research Organization:
- Columbia Univ., New York (USA)
- OSTI ID:
- 5241994
- Country of Publication:
- United States
- Language:
- English
Similar Records
In vivo binding of /sup 125/I-LSD to serotonin 5-HT/sub 2/ receptors in mouse brain
In vivo labeling of 5-hydroxytryptamine uptake sites in mouse brain with ( sup 3 H)-6-nitroquipazine
Differential binding of /sup 3/H-imipramine and /sup 3/H-mianserin in rat cerebral cortex
Journal Article
·
Mon Aug 19 00:00:00 EDT 1985
· Life Sci.; (United States)
·
OSTI ID:5438697
In vivo labeling of 5-hydroxytryptamine uptake sites in mouse brain with ( sup 3 H)-6-nitroquipazine
Journal Article
·
Mon Oct 01 00:00:00 EDT 1990
· Journal of Pharmacology and Experimental Therapeutics; (USA)
·
OSTI ID:6213521
Differential binding of /sup 3/H-imipramine and /sup 3/H-mianserin in rat cerebral cortex
Journal Article
·
Sun Nov 15 23:00:00 EST 1981
· Life Sci.; (United States)
·
OSTI ID:5801965
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL CELLS
ANIMALS
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CATECHOLAMINES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
ESTRADIOL
ESTRANES
ESTROGENS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IMIPRAMINE
INDOLES
INHIBITION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MALES
MAMMALS
NERVE CELLS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PSYCHOTROPIC DRUGS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RATS
REACTION KINETICS
RODENTS
SEROTONIN
SOMATIC CELLS
STEROID HORMONES
STEROIDS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TRYPTAMINES
UPTAKE
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL CELLS
ANIMALS
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CATECHOLAMINES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
ESTRADIOL
ESTRANES
ESTROGENS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IMIPRAMINE
INDOLES
INHIBITION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MALES
MAMMALS
NERVE CELLS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PSYCHOTROPIC DRUGS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RATS
REACTION KINETICS
RODENTS
SEROTONIN
SOMATIC CELLS
STEROID HORMONES
STEROIDS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TRYPTAMINES
UPTAKE
VERTEBRATES