Murine lethal milk mutation causes maternal accumulation of zinc in intestine and kidney and reduced zinc transport to milk

Conference · Fri Mar 15 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5239828

Lee, Dohyeel; Cousins, R J ^[1]

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1. Univ. of Florida, Gainesville (United States)

The lethal milk (Lm) mutation is autosomal recessive in C57BL/6J mice and causes Zn deficiency in pups nursed by Lm dams. The genetic defect may cause a shift in the tissue Zn distribution in Lm dams since their milk has a 34-45% lower Zn concentration than milk of normal (N) dams. To examine tissue Zn distribution and Zn transport to milk and pups, 1 {mu}Ci of {sup 65}Zn was administered ip to lactating N and Lm dams. They also received 800 {mu}g Zn/ml in their drinking water to preclude short term, terminal zinc deficiency in the neonates nursed by Lm dams. {sup 65}Zn content of milk and tissues of dams and tissues of pups was measured. Transport of {sup 65}Zn to milk of Lm dams was about 50% compared to milk of N dams. The percentage of the {sup 65}Zn dose recovered in the intestine, liver, and kidney of N pups nursed by LM dams was markedly lower than those of N pups nursed by N dams. In contrast, the percentage of {sup 65}Zn in the intestine and kidney of Lm dams was about twice that of N dams. The elevated intestinal {sup 65}Zn was paralleled by and elevated metallothionein concentration, but the increased {sup 65}Zn in the kidney was not. The Lm gene defect might limit Zn transport to milk by shifting the Zn distribution in lactating dams to the intestine, kidney, and perhaps other tissues.

• OSTI ID: 5239828
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FOOD
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MEMBRANE TRANSPORT
METABOLISM
METALS
MICE
MILK
MUTATIONS
NUCLEI
RADIOISOTOPES
RECESSIVE MUTATIONS
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
ZINC
ZINC 65
ZINC ISOTOPES