Aldehydes and hydrogen peroxide as mediators of ozone toxicity
- Louisiana State Univ., Baton Rouge, (United States)
The unsaturated fatty acids (UFA) in lung lining fluids and cell membranes are a primary target for the reaction of ozone in the lung. The authors propose that ozone reacts with UFA in loci that are sufficiently aquated so the carbonyl oxide is captured by water. The data show that the stoichiometry and products from the reaction of ozone with either emulsions of UFA from oleic through arachidonate or with liposomes made from dioleoyl phosphadidyl choline (PC) are accurately described by eq 1. Soy PC also gives 1 mole of H{sub 2}O{sub 2} per mol of ozone used. Rat lung lavage and rat rbc ghosts give ca. 50% yields of H{sub 2}O{sub 2} based on ozone reacted, presumably due to the reaction of thiol-containing proteins with ozone to give H{sub 2}O{sub 2}. Thus, aldehydes and H{sub 2}O{sub 2} can be used as markers of ozone damage and probably are responsible for much of the pathology caused by ozone, particularly at sites other than immediate air/tissue boundary.
- OSTI ID:
- 5239088
- Report Number(s):
- CONF-9104107--
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 5:5; ISSN 0892-6638; ISSN FAJOE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MARKERS
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
INHALATION
INTAKE
LAVAGE
LUNGS
MAMMALS
MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
OZONE
PEROXIDES
RATS
RESPIRATORY SYSTEM
RODENTS
SENSITIVITY
STOICHIOMETRY
TOXICITY
VERTEBRATES