Genotoxic effects of cisplatin in somatic tissue of Drosophila melanogaster

Journal Article · Thu Jan 01 04:00:00 EST 1987 · Environ. Mutagen.; (United States)

OSTI ID:5238001

Katz, A J

Third instar larvae of Drosophila melanogaster transdihybrid for mwh and flr were exposed to varying concentrations of cisplatin by feeding on dry media wetted with aqueous solutions of the test compound. Larval feeding continued until pupation, and surviving transdihybrid adults were collected seven days following commencement of feeding. Wings of adults were removed and scored under 400X magnification for the presence of twin spots and single spots comprised of clones of cells possessing malformed wing hairs. Cisplatin was found to induce both twin spots and single spots, and significant linear concentration-response relationships were obtained with respect to the induction of all endpoints. This capacity to induce mitotic exchange in the somatic tissue of Drosophila compares well with the compound's reported ability to induce chromosome breaks in Drosophila germ cells. However, not all compounds possess similar genotoxic profiles in the somatic an germ tissue of Drosophila.

• Research Organization: Illinois State Univ., Normal
• OSTI ID: 5238001
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 10:2; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
CHROMOSOMAL ABERRATIONS
DIPTERA
DROSOPHILA
FLIES
FRUIT FLIES
GENETIC EFFECTS
INSECTS
INVERTEBRATES
MUTATIONS
PLATINUM COMPOUNDS
SOMATIC CELLS
SOMATIC MUTATIONS
TRANSITION ELEMENT COMPOUNDS