Cerebral blood flow changes during sodium-lactate-induced panic attacks

Journal Article · Fri Apr 01 00:00:00 EST 1988 · Am. J. Psychiatry; (United States)

OSTI ID:5237918

Stewart, R S; Devous, Sr, M D; Rush, A J; Lane, L; Bonte, F J

Dynamic single-photon emission computed axial tomography (CAT) with inhaled xenon-133 was used to measure regional cerebral blood flow in 10 drug-free patients with DSM-III-diagnosed panic disorder and in five normal control subjects. All subjects underwent regional cerebral blood flow studies while at rest or during normal saline infusion and during sodium lactate infusion. Six of the 10 patients and none of the control subjects experienced lactate-induced panic attacks. Lactate infusion markedly raised hemispheric blood flow levels in both control subjects and patients who did not panic. Patients who did panic experienced either a minimal increase or a decrease in hemispheric blood flow.

• Research Organization: Univ. of Texas Southwestern Medical Center, Dallas (USA)
• OSTI ID: 5237918
• Journal Information: Am. J. Psychiatry; (United States), Vol. 145:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CEREBRAL CORTEX
BLOOD FLOW
NERVOUS SYSTEM DISEASES
DIAGNOSIS
LACTATES
PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
TOMOGRAPHY
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics