Cardio-pulmonary effects of inhaled solvents: computer-assisted measurement and analysis

Thesis/Dissertation · Wed Jan 01 00:00:00 EST 1986

OSTI ID:5237826

Engwall, M J

The physiological effects of the inhalation of three solvent vapors were measured on anesthetized dogs. The tested solvents were: acetone, ethanol, and toluene. Measurements of respiratory mechanics, pulmonary and systemic hemodynamics, cardiac output, and gas-exchange were taken while exposing the animals to the vaporized solvents. After the exposures, the animals were terminated and lung tissue and alveolar lining material (ALM) were collected. The ALM was analyzed by high performance liquid chromatography for the amounts of component phospholipids. The tissues were inspected under light microscopy for evidence of acute damage associated with the solvent exposures.

• Research Organization: Iowa State Univ. of Science and Technology, Ames (USA)
• OSTI ID: 5237826
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETONE
TOXICITY
ETHANOL
LUNGS
ULTRASTRUCTURAL CHANGES
ORGANIC SOLVENTS
TOLUENE
COMPUTER CALCULATIONS
DOGS
INHALATION
LIQUID COLUMN CHROMATOGRAPHY
ALCOHOLS
ALKYLATED AROMATICS
ANIMALS
AROMATICS
BODY
CHROMATOGRAPHY
HYDROCARBONS
HYDROXY COMPOUNDS
INTAKE
KETONES
MAMMALS
MORPHOLOGICAL CHANGES
ORGANIC COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
SEPARATION PROCESSES
SOLVENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology