Differential growth of allogeneic bone marrow and leukemia cells in irradiated guinea pigs
Growth of normal bone marrow and L/sub 2/C leukemia cell grafts was studied in lethally irradiated strain 2 and strain 13 guinea pigs. Allogeneic bone marrow cells proliferated as well as syngeneic cells in both strain 2 and 13 animals. This observation indicates that Ia disparities are not relevant to marrow graft rejection in the guinea pig. Both Ia positive and Ia negative L/sub 2/C leukemia cells of strain 2 origin grew well in the spleen of irradiated strain 2 animals. However, irradiated strain 13 animals showed resistance to the growth of both leukemia cell lines. F/sub 1/ hybrids (2 x 13) also showed resistance to the growth of the leukemia cells. These observations suggest the existence of an effector system capable of mediating natural resistance to L/sub 2/C cells in unimmunized strain 13 and F/sub 1/ guinea pigs. The nature of antigens recognized by these radiation resistant effector cells are not entirely clear. However, Ia antigens, or tumor-associated antigens dependent upon Ia antigens for immunogenicity, do not seem to be the primary targets in this phenomenon.
- Research Organization:
- Massachusetts General Hospital, Boston
- OSTI ID:
- 5236466
- Journal Information:
- J. Immunol.; (United States), Vol. 123:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Tolerance, immunocompetence, and secondary disease in fully allogeneic radiation chimeras
Effect of selective T cell depletion of host and/or donor bone marrow on lymphopoietic repopulation, tolerance, and graft-vs-host disease in mixed allogeneic chimeras (B10 + B10. D2----B10)
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BONE MARROW CELLS
CELL PROLIFERATION
IMMUNE REACTIONS
BIOLOGICAL RADIATION EFFECTS
RADIOSENSITIVITY
GENETIC VARIABILITY
RECEPTORS
TUMOR CELLS
ANTIGENS
CESIUM 137
GAMMA RADIATION
GUINEA PIGS
HISTOLOGY
LETHAL IRRADIATION
LEUKEMIA
PATHOLOGY
SPLEEN
WHOLE-BODY IRRADIATION
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BODY
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
HEMIC DISEASES
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
550400 - Genetics
550900 - Pathology