Toxicity of abdominopelvic radiation in advanced ovarian carcinoma patients after cisplatin/cyclophosphamide therapy and second-look laparotomy

Journal Article · Tue Mar 01 04:00:00 EST 1988 · Obstet. Gynecol.; (United States)

OSTI ID:5234932

Shelley, W E; Starreveld, A A; Carmichael, J A; O'Connell, G; Roy, M; Swenerton, K

Twenty-seven advanced ovarian carcinoma patients who had received six courses of cyclophosphamide/cisplatin and had either microscopic disease (15 patients) or no pathologically detectable disease (12 patients) after second-look laparotomy were treated with abdominopelvic radiation (2250 cGy to the abdomen and pelvis and a 2250-cGy pelvic boost). Acute myelosuppression or gastrointestinal toxicity prevented completion of treatment in only three patients. However, bowel obstruction occurred in 13 (48%), ten of whom required surgery. Five of these ten had recurrent tumor, but the other five did not. Subsequently two of the latter five did develop a recurrence, one in the lung and one in the liver. A third patient died as an indirect result of radiation damage to the bowel. Median follow-up duration is 17 months from completion of radiation. So far, 13 (48%) have developed progressive disease: four (33%) of the 12 who had a negative second-look laparotomy and nine (60%) of the 15 who had microscopic disease before radiation. While acute toxicity is tolerable, the incidence of serious chronic bowel toxicity is high. Efforts should be made to alter this therapy in order to decrease the frequency of long-term morbidity.

• Research Organization: Queen's Univ., Kingston, Ontario (Canada)
• OSTI ID: 5234932
• Journal Information: Obstet. Gynecol.; (United States), Journal Name: Obstet. Gynecol.; (United States) Vol. 71; ISSN OBGNA
• Country of Publication: United States
• Language: English

Related Subjects

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560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
COMBINED THERAPY
DIARRHEA
DISEASES
FEMALE GENITALS
GONADS
INJURIES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
OVARIES
PAIN
PATIENTS
PELVIS
POST-IRRADIATION EXAMINATION
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
SYMPTOMS
THERAPY
TOXICITY