Effect of alcohol on behavioral and autonomic thermoregulation in mice
Male, BALB/c mice were injected intraperitoneally with ethyl alcohol (ethanol) in dosages of 0, 0.03, 0.1, 0.3, 1.0, or 3.0 g/kg and then placed in a temperature gradient that permitted the measurement of preferred ambient temperature (Ta). The 3 g/kg dosage of ethanol resulted in a slight lowering of the preferred Ta during the first 30 min of placement in the gradient. However, there was no overall statistically significant effect of alcohol dosage on preferred Ta. In another experiment, BALB/c mice were treated with the aforementioned ethanol dosages while metabolic rate (MR), evaporative water loss (EWL), and colonic temperature were measured 60 min post-injection at Ta's of 20, 30, and 35 C a dosage of 3 g/kg caused a significant decrease in MR, EWL, and colonic temperature. At a Ta of 30 C this same dosage caused significant reduction in colonic temperature, however; at Ta of 35 C ethanol had no effect on these parameters. In spite of the significant decrease in colonic temperature at a Ta of 30 C, which approximates the normal preferred Ta, the behavioral thermal preference was marginally affected. It is not clear whether or not ethanol injection results in a decrease in the set-point body temperature.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5231960
- Report Number(s):
- PB-88-171111/XAB
- Resource Relation:
- Other Information: Pub. in Alcohol, Vol. 3, 339-343(1986)
- Country of Publication:
- United States
- Language:
- English
Similar Records
Behavioral and autonomic thermoregulation in hamsters during microwave-induced heat exposure
Body temperature in the mouse, hamster, and rat exposed to radiofrequency radiation: an interspecies comparison
Related Subjects
ALCOHOLS
BIOLOGICAL EFFECTS
MICE
THERMOREGULATION
BEHAVIOR
BODY TEMPERATURE
DEHYDRATION
LABORATORY ANIMALS
METABOLISM
ANIMALS
CONTROL
HYDROXY COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
RODENTS
TEMPERATURE CONTROL
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology