Dioxins and dibenzofurans in blood and adipose tissue of Agent Orange-exposed Vietnam veterans and matched controls

Journal Article · Fri Mar 18 00:00:00 EST 1988 · JAMA, J. Am. Med. Assoc.; (United States)

DOI:https://doi.org/10.1001/jama.1988.03720110023029· OSTI ID:5231262

Kahn, P C; Gochfeld, M; Nygren, M; Hansson, M; Rappe, C; Velez, H; Ghent-Guenther, T; Wilson, W P

Vietnam veterans who were heavily exposed to Agent Orange exceeded matched control subjects in both blood and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but not in the levels of the 12 other 2,3,7,8-substituted dioxins and dibenzofurans that were detected. Since only TCDD among these compounds was present in Agent Orange but all are present in the population of the industrialized world, it is likely that the elevated TCDD levels arose from wartime exposure. The high correlation (r = +.89) of blood with adipose tissue level suggests that there may be a mobile equilibrium between them and that blood measurement could replace adipose tissue measurement of TCDD levels, making the collection of human data less invasive.

• Research Organization: Rutgers Univ., New Brunswick, NJ (USA)
• OSTI ID: 5231262
• Journal Information: JAMA, J. Am. Med. Assoc.; (United States), Vol. 259:11
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOFURANS
TISSUE DISTRIBUTION
CHEMICAL WARFARE AGENTS
HEALTH HAZARDS
DIOXIN
ADIPOSE TISSUE
BIOLOGICAL HALF-LIFE
BLOOD
BODY BURDEN
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VIET NAM
ANIMAL TISSUES
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BODY FLUIDS
CONNECTIVE TISSUE
DEVELOPING COUNTRIES
DISTRIBUTION
FURANS
HAZARDS
HETEROCYCLIC COMPOUNDS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PERSONNEL
TISSUES
WEAPONS
560300* - Chemicals Metabolism & Toxicology