Age-related ozone effects on glucose utilization in rat lungs

Technical Report · Sun Jan 01 04:00:00 EST 1984

OSTI ID:5229993

Postlethwait, E M; Mustafa, M G; Elsayed, N M

The authors examined the relationship between animal age and pulmonary biochemical effects of O/sub 3/ exposure using young to adult rats ranging in age from 24 to 90 days. Glucose uptake and production of pyruvate and lactate, determined in lung tissue slices, were used as indices of O/sub 3/-produced metabolic alterations. In control rats, the lung weights increased with animal age until they stabilized between 60 and 90 days of age. The rate of glucose metabolism, expressed per lung, increased with animal age paralleling the increase in lung weights. After exposure to 0.8 ppm (1568 ug/m3)O/sub 3/ for 3 days, the lung weights and all three parameters of glucose metabolism increased in exposed rats relative to their age-matched controls.

• Research Organization: California Univ., Los Angeles (USA)
• OSTI ID: 5229993
• Report Number(s): PB-86-213717/XAB
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
GLUCOSE
HEXOSES
LUNGS
METABOLISM
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
OZONE
RESPIRATORY SYSTEM
SACCHARIDES