Neonatal and maternal body burdens of hexachlorobenzene (HCB) in mice: gestational exposure and lactational transfer

Journal Article · Sun Mar 31 23:00:00 EST 1985 · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/0272-0590(85)90074-0· OSTI ID:5229265

Courtney, K D; Andrews, J E

Hexachlorobenzene (HCB), a ubiquitous lipophilic pollutant, was readily transferred in the milk of lactating dams to their suckling neonates. Pregnant CD-1 mice were treated during gestation, and the body burdens of HCB in the neonates and the dams were determined during lactation. Also, neonates from dams treated with HCB during gestation were cross-fostered at birth to dams treated with corn oil during gestation. The body burdens of HCB were greater in the neonates exposed to HCB by lactational transfer than the neonates exposed only by gestational transfer. In many tissues, the concentration of HCB in the pups from full litter was similar to that in pups from litters reduced to two pups per litter. Lactational transfer of HCB from the dams to the pups was a major route of excretion in that 95% of HCB was depleted during 20 days of lactation. HCB depletion was similar in dams with whole litters, and those with litters reduced to two pups.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC
• OSTI ID: 5229265
• Journal Information: Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 2; ISSN FAATD
• Country of Publication: United States
• Language: English

Related Subjects

550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
AGING
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BODY
BODY BURDEN
BODY FLUIDS
CHLORINATED AROMATIC HYDROCARBONS
DIGESTIVE SYSTEM
DISTRIBUTION
FOOD
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
LACTATION
LIVER
MAMMALS
MATERIALS
MEMBRANE TRANSPORT
MICE
MILK
NEONATES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PREGNANCY
RODENTS
TISSUE DISTRIBUTION
VERTEBRATES