Collagen macromolecular drug delivery systems

Thesis/Dissertation · Fri Jan 01 00:00:00 EST 1988

OSTI ID:5228916

Gilbert, D L

The objective of this study was to examine collagen for use as a macromolecular drug delivery system by determining the mechanism of release through a matrix. Collagen membranes varying in porosity, crosslinking density, structure and crosslinker were fabricated. Collagen characterized by infrared spectroscopy and solution viscosity was determined to be pure and native. The collagen membranes were determined to possess native vs. non-native quaternary structure and porous vs. dense aggregate membranes by electron microscopy. Collagen monolithic devices containing a model macromolecule (inulin) were fabricated. In vitro release rates were found to be linear with respect to t{sup {1/2}} and were affected by crosslinking density, crosslinker and structure. The biodegradation of the collagen matrix was also examined. In vivo biocompatibility, degradation and {sup 14}C-inulin release rates were evaluated subcutaneously in rats.

• Research Organization: Utah Univ., Salt Lake City, UT (USA)
• OSTI ID: 5228916
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
COLLAGEN
MEMBRANE TRANSPORT
DRUGS
CARBON 14 COMPOUNDS
CELL MEMBRANES
CHEMICAL COMPOSITION
CROSS-LINKING
ELECTRON MICROSCOPY
INFRARED SPECTRA
INULIN
METABOLISM
MOLECULAR STRUCTURE
RATS
TRACER TECHNIQUES
ANIMALS
CARBOHYDRATES
CELL CONSTITUENTS
CHEMICAL REACTIONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
MICROSCOPY
ORGANIC COMPOUNDS
POLYMERIZATION
POLYSACCHARIDES
PROTEINS
RODENTS
SACCHARIDES
SCLEROPROTEINS
SPECTRA
VERTEBRATES
550201* - Biochemistry- Tracer Techniques