Relationship between lung colony and in situ assays

Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90338-4· OSTI ID:5227794

Ando, K; Koike, S

The relationship between different assays: tumor control, tumor growth delay and lung colony formation was examined after fast neutron and ..gamma.. ray irradiations. Fibrosarcomas (NFSa) in syngeneic C3Hf mice were irradiated locally with /sup 60/Co ..gamma.. rays, fast neutrons or mixed beams (..gamma.. rays and fast neutrons). A comparison between the lung colony assay and the TRT/sub 50/ (50% tumor growth delay time) assay when cells were exposed to single doses of fast neutrons or ..gamma.. rays, resulted in identical growth delay times. The fraction of cells surviving a single dose of fast neutrons, was 10 times higher than the surviving fraction of cells after a single dose of ..gamma.. rays. Both doses resulted in the same tumor control probability (TCD/sub 50/ assay). Neither repair of potentially lethal damage nor tumor bed effect was sufficient to explain the difference between cell survival and tumor control probability. The surviving fraction of cells following fractionated irradiations of ..gamma.. rays and fast neutrons were identical at 50% tumor control probabilities.

• Research Organization: National Institute of Radiological Sciences, Chiba, Japan
• OSTI ID: 5227794
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL KILLING
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
FIBROSARCOMAS
GAMMA RADIATION
GROWTH
HADRONS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RECOVERY
REPAIR
RESPIRATORY SYSTEM
SARCOMAS
THERAPY
YEARS LIVING RADIOISOTOPES