Cadmium-Induced Bone Loss: Increased Susceptibility in Female Beagles after Ovariectomy

Conference · Wed Sep 25 00:00:00 EDT 1991

OSTI ID:5227243

Bhattacharyya, M. H. ^[1]; Sacco-Gibson, N. A. ^[1]; Peterson, D. P. ^[1]

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1. Argonne National Laboratory (ANL), Argonne, IL (United States)

Bone resorption, as measured by release of bone ⁴⁵Ca, was significantly increased in elderly female beagles within % h of exposure to 15 mg/L Cd in drinking water. The ⁴⁵Ca response was greater in ovariectomized (OV) animals than in sham-operated (SO) controls and was not mediated by changes in calciotropic hormone concentrations. Mean blood Cd concentrations were 3-8 μg/L during the earliest bone resorption response and 13-15 μg/L at the end of the study. During 7 mo of Cd exposure, bone mineral densities decreased most in the OV animals exposed to Cd: -15.4 ± 4.3% for the tibia distal end and -7.2 ± 1.2% for the lumbar vertebrae (L2-L4) (mean ± SE, n=4). Results indicate that Cd may act directly on bone and that postmenopausal women exposed to Cd in industry or via cigarette smoke may be at increased risk of Cd-induced bone loss.

• Research Organization: Argonne National Laboratory (ANL), Argonne, IL (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institutes of Health (NIH)
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 5227243
• Report Number(s): ANL/CP-72578; CONF-9109265--1; ON: DE91018623
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMAL TISSUES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BODY
BONE TISSUES
CADMIUM
CALCIUM 45
CALCIUM ISOTOPES
CHRONIC EXPOSURE
CONNECTIVE TISSUE
Cadmium
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ESTROGENS
EVEN-ODD NUCLEI
FEMALE GENITALS
GONADS
HORMONES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
Itai-Itai disease
MAMMALS
MENOPAUSE
METALS
NUCLEI
ORGANS
OSTEOPOROSIS
OVARIES
RADIOISOTOPES
SKELETAL DISEASES
STEROID HORMONES
TISSUES
TRACER TECHNIQUES
VERTEBRATES
VITAMIN D
VITAMINS
bone
dog
ovariectomy
postmenopausal osteoporosis