Streptococcal cell wall-induced arthritis and adjuvant arthritis in F344----Lewis and in Lewis----F344 bone marrow chimeras

Journal Article · Sun Sep 01 04:00:00 EDT 1991 · Cellular Immunology; (United States)

DOI:https://doi.org/10.1016/0008-8749(91)90352-C· OSTI ID:5227095

van Bruggen, M C; van den Broek, M F; van den Berg, W B ^[1]

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1. University Hospital Nijmegen, (Netherlands)

Streptococcal cell wall (SCW)-induced arthritis and adjuvant arthritis (AA) are rat models for chronic, erosive polyarthritis. Both models can be induced in susceptible Lewis rats, whereas F344 rats are resistant. In AA as well as in SCW arthritis, antigen-specific T lymphocytes have been demonstrated to be crucial for chronic disease. In this communication the authors describe their studies to probe the cellular mechanism responsible for the difference in susceptibility of Lewis and F344, using bone marrow chimeras. By transplanting bone marrow cells from F344 into lethally irradiated Lewis recipients, Lewis rats were rendered resistant to SCW arthritis induction. F344 rats reconstituted with Lewis bone marrow, i.e., Lewis----F344 chimeras, develop an arthritis upon SCW injection. For AA comparable results were obtained. These data suggest that both resistance and susceptibility to bacterium-induced chronic arthritis are mediated by hemopoietic/immune cells and that the recipiental environment does not influence the susceptibility to chronic joint inflammation.

• OSTI ID: 5227095
• Journal Information: Cellular Immunology; (United States), Journal Name: Cellular Immunology; (United States) Vol. 136:2; ISSN 0008-8749; ISSN CLIMB
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BACTERIA
BONE MARROW CELLS
CELL CONSTITUENTS
CELL WALL
CHIMERAS
CONNECTIVE TISSUE CELLS
DISEASE RESISTANCE
DISEASES
IMMUNITY
MAMMALS
MICROORGANISMS
MOSAICISM
RADIATION CHIMERAS
RADIOINDUCTION
RATS
RHEUMATIC DISEASES
RODENTS
SKELETAL DISEASES
SOMATIC CELLS
STREPTOCOCCUS
TRANSPLANTS
VERTEBRATES