Monoclonal antibodies in the treatment of cancer

Journal Article · Sun Jan 01 00:00:00 EST 1984 · CRC Crit. Rev. Oncol. Hematol.; (United States)

DOI:https://doi.org/10.1016/S1040-8428(84)80008-6· OSTI ID:5220194

Dillman, R O

Potential uses of monoclonal antibodies in anti-cancer treatment include passive serotherapy, radioisotope conjugates, toxin-linked conjugates, and chemotherapy-monoclonal antibody conjugates. The bases for these applications have been founded in research with heterologous antisera, and in some cases with monoclonal antibodies in animal tumor models. Human trials with passive serotherapy have already begun in both hematopoietic and solid tumor malignancies. Promising results have been reported in cutaneous T cell lymphoma with anti-T cell monoclonal antibody, and in nodular lymphoma with anti-idiotype monoclonal antibody. Radioisotope conjugate work appears promising for imaging in both animals and humans, and this work will lay the foundation for possible therapeutic application of radio-immunotherapy. Toxin-linked conjugates are promising in vitro and may have application in autologous bone marrow transplantation. Research with chemotherapy conjugates is also underway. Preliminary results suggest that murine monoclonal antibodies will be well tolerated clinically except in the setting of circulating cells which bear the target antigen, where rapid infusions may be associated with intolerable side effects. In certain diseases, production of endogenous anti-mouse antibodies may also limit application. Advances in the technology for human-human hybridoma production may help solve some of these problems. 132 references.

• Research Organization: Univ. of California, San Diego
• OSTI ID: 5220194
• Journal Information: CRC Crit. Rev. Oncol. Hematol.; (United States), Vol. 1:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
MONOCLONAL ANTIBODIES
USES
NEOPLASMS
IMMUNOTHERAPY
RADIOTHERAPY
ANTIGENS
BIOLOGICAL MODELS
CHEMOTHERAPY
HYBRIDOMAS
LYMPHOMAS
RADIOISOTOPES
TOXINS
ANIMAL CELLS
ANTIBODIES
DISEASES
ISOTOPES
MATERIALS
MEDICINE
NUCLEAR MEDICINE
RADIOLOGY
THERAPY
TOXIC MATERIALS
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