Widespread distribution of brain dopamine receptors evidenced with (/sup 125/I)iodosulpride, a highly selective ligand
Journal Article
·
· Science (Washington, D.C.); (United States)
The new benzamide derivative (/sup 125/I)iodosulpride is a highly sensitive and selective ligand for D-2 dopamine receptors and displays a very low nonspecific binding to membrane or autoradiographic sections. On autoradiographic images, D-2 receptors are present not only in well-established dopaminergic areas but also, in a discrete manner, in a number of catecholaminergic regions in which the dopaminergic innervation is still unknown, imprecise, or controversial, as in the sensorimotor cerebral cortex or cerebellum. This widespread distribution suggests larger physiological and pathophysiological roles for cerebral dopamine receptors than was previously thought.
- Research Organization:
- Centre Paul Broca de l'INSERM, Paris, France
- OSTI ID:
- 5219638
- Journal Information:
- Science (Washington, D.C.); (United States), Vol. 4700
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
AUTORADIOGRAPHY
IODINE 125
TISSUE DISTRIBUTION
RECEPTORS
AMIDES
CEREBELLUM
CEREBRAL CORTEX
DOPAMINE
HIPPOCAMPUS
LIGANDS
RATS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RADIOISOTOPES
RODENTS
SYMPATHOMIMETICS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
BRAIN
AUTORADIOGRAPHY
IODINE 125
TISSUE DISTRIBUTION
RECEPTORS
AMIDES
CEREBELLUM
CEREBRAL CORTEX
DOPAMINE
HIPPOCAMPUS
LIGANDS
RATS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RADIOISOTOPES
RODENTS
SYMPATHOMIMETICS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics