Assessment of glomerular filtration rate and effective renal plasma flow in cystic fibrosis
A study was conducted to examine renal function in 10 healthy control subjects and eight patients with cystic fibrosis in stable condition. Sequential bolus injections of /sup 99m/Tc-DTPA and /sup 125/I-OIH were administered to assess glomerular filtration rate and effective renal plasma flow, respectively. Blood was subsequently collected for 3 hours, and urine for 24 hours. Renal clearances of both radioisotope markers were virtually identical in patients and controls. Inasmuch as neither glomerular filtration rate nor effective renal plasma flow was enhanced in patients with cystic fibrosis, increased clearance of drugs in these patients is unlikely to be the result of enhanced glomerular filtration or tubular secretion.
- Research Organization:
- Univ. of Toronto, Ontario, Canada
- OSTI ID:
- 5218389
- Journal Information:
- J. Pediatr.; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
KIDNEYS
DYNAMIC FUNCTION STUDIES
BLOOD FLOW
DTPA
HEREDITARY DISEASES
IODINE 125
ISOMERIC NUCLEI
LABELLED COMPOUNDS
PATIENTS
RENAL CLEARANCE
TECHNETIUM 99
TRACER TECHNIQUES
URINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
TECHNETIUM ISOTOPES
WASTES
YEARS LIVING RADIOISOTOPES
550901* - Pathology- Tracer Techniques