Chelation in metal intoxication XXI: chelation in lead intoxication during vitamin B complex deficiency

Journal Article · Mon Sep 01 04:00:00 EDT 1986 · Bull. Environ. Contam. Toxicol.; (United States)

OSTI ID:5217119

The vitamin B-complex deficiency increases the vulnerability to neuro- and systemic toxicity of Pb in young rats. Thus, the nutritional status of vitamins like that of protein or minerals seems to influence the etiology of Pb toxicity and may be expected to affect the response toward Pb chelators. 2,3 dimercaptosuccinic acid (DMSA) and N-(2-hydroxyethyl) ethylene-diamine triacetic acid (HEDTA) have been found to be effective antidotes to Pb intoxication. In the present study, these selective metal chelating agents were compared for their ability to reduce the body burden of Pb and restore the altered biochemical parameters in young developing Pb intoxicated rats maintained on normal or vitamin B-complex deficient diet. The investigation was aimed to suggest suitable prophylaxis of Pb poisoning prevalent among children who may also be suffering from vitamin deficiency in developing and poor countries.

• Research Organization: Industrial Toxicology Research Centre, Lucknow, India
• OSTI ID: 5217119
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 37:3; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMISTRY
HEDTA
HYDROXY ACIDS
LEAD COMPOUNDS
MAMMALS
NUTRITIONAL DEFICIENCY
ORGANIC ACIDS
ORGANIC COMPOUNDS
RATS
RODENTS
UPTAKE
VERTEBRATES
VITAMIN B GROUP
VITAMINS