High-LET charged particle radiotherapy

Conference · Mon Jul 01 04:00:00 EDT 1991

OSTI ID:5216469

Castro, J R ^[1]

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1. Lawrence Berkeley Lab., CA (United States). Research Medicine and Radiation Biophysics Div. California Univ., San Francisco, CA (United States). Dept. of Radiation Oncology

The Department of Radiation Oncology at UCSF Medical Center and the Radiation Oncology Department at UC Lawrence Berkeley Laboratory have been evaluating the use of high LET charged particle radiotherapy in a Phase 1--2 research trial ongoing since 1979. In this clinical trail, 239 patients have received at least 10 Gy (physical) minimum tumor dose with neon ions, meaning that at least one-half of their total treatment was given with high-LET charged particle therapy. Ninety-one patients received all of their therapy with neon ions. Of the 239 patients irradiated, target sites included lesions in the skin, subcutaneous tissues, head and neck such as paranasal sinuses, nasopharynx and salivary glands (major and minor), skull base and juxtaspinal area, GI tract including esophagus, pancreas and biliary tract, prostate, lung, soft tissue and bone. Analysis of these patients has been carried out with a minimum followup period of 2 years.

• Research Organization: Lawrence Berkeley Lab., CA (United States)
• Sponsoring Organization: DOE; NIOSH; USDOE, Washington, DC (United States); National Inst. for Occupational Safety and Health, Rockville, MD (United States)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 5216469
• Report Number(s): LBL-31545; CONF-9107136--12; ON: DE92014505; CNN: CA 19138
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
CHARGED PARTICLES
DISEASES
HELIUM IONS
IONS
MEDICINE
NEON IONS
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIOLOGY
RADIOTHERAPY
THERAPY
TISSUES