Radiopharmaceutical treatment of malignant pheochromocytoma

Journal Article · Wed Feb 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:5216141

Sisson, J C; Shapiro, B; Beierwaltes, W H

Apart from relieving effects of secreted catecholamines, treatments of malignant pheochromocytoma have achieved little success. When the radiopharmaceutical, meta-(/sup 131/I) iodobenzylguanidine (I-131 MIBG), was found to concentrate in some malignant pheochromocytomas, the authors calculated that this agent could impart therapeutic doses of radiation to these tumors. They therefore treated five patients with two to four doses of I-131 MIBG prepared in high specific activity, 8-11 Ci/mmol. Individual doses were given at 3- to 10-mo intervals and in 97- to 197-mCi amounts. Two patients exhibited subjective and objective benefits. Their tumors declined in size (to 28% and 30% of original volumes) and in hormone secretion (to 50% or less of baseline rates). The other three patients manifested few symptoms before treatment and showed few or no objective improvements afterward. No toxic effects were encountered during the treatments, and only minor and temporary untoward responses were seen later.

• Research Organization: Univ. of Michigan Medical Center, Ann Arbor
• OSTI ID: 5216141
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BODY
BODY AREAS
CARBONIC ACID DERIVATIVES
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
DRUGS
GUANIDINES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
SIDE EFFECTS
SKELETON
THERAPY