Interactive effects of manganese and/or iron supplementation in adult women
- Univ. of Wisconsin, Madison (United States)
Evaluation of the practical significance of manganese-iron interactions has been hampered by the limited methodologies available to assess manganese status. Manganese status has not been monitored longitudinally in control studies with humans. Forty-eight women were recruited for a double blind 125-day supplementation study. After an initial 5-day baseline period, subjects were assigned to one of four treatments: placebo; 30 mg iron as ferrous fumarate daily; 15 mg manganese as an amino acid chelated manganese supplement daily or both the iron and manganese supplements daily. Dietary information, blood and 3-day urine samples were collected during the baseline period and after 20, 55, 85 and 120 days of consuming the supplements. Urinary manganese excretion ranged from 0.11 to 1.40 {mu}g/day. Serum manganese ranged from 0.16 to 1.92 {mu}g/l. Serum was also analyzed for iron, zinc, copper, ferritin and transferrin concentrations. Lymphocytes were isolated and manganese-dependent superoxide dismutase activity was determined as a new method to assess manganese status. Plasma cholesterol ranged from 126 to 229 mg/dl and HDL cholesterol ranged from 31 to 84 mg/dl. Plasma triglycerides were determined and LDL cholesterol was calculated by difference.
- OSTI ID:
- 5213461
- Report Number(s):
- CONF-9104107-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IRON
BIOLOGICAL EFFECTS
MANGANESE
SUPEROXIDE DISMUTASE
ENZYME ACTIVITY
BLOOD CHEMISTRY
CHOLESTEROL
LYMPHOCYTES
METABOLISM
WOMEN
ANIMAL CELLS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMISTRY
CONNECTIVE TISSUE CELLS
ELEMENTS
ENZYMES
FEMALES
HYDROXY COMPOUNDS
LEUKOCYTES
MAMMALS
MAN
MATERIALS
METALS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PRIMATES
PROTEINS
SOMATIC CELLS
STEROIDS
STEROLS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology