Molecular basis for inhibition of mitochondrial respiration by naphthalene
Journal Article
·
· Bull. Environ. Contam. Toxicol.; (United States)
Naphthalenes, abundant in coal tar, synthetic, and natural crude oils, have been detected in industrial and sewage plant effluents, and in drinking waters. Naphthalene inhibits oxygen consumption by isolated cardiac mitochondria (NADH-O/sub 2/) with an EC/sub 50/ value of 78 ..mu..M. It also inhibits oxygen consumption by three types of tissue culture cells. Naphthalene affects ubiquinone (UQ) reduction by NADH as well as UQH/sub 2/ oxidation by O/sub 2/ with no effect on duroquinol oxidation. This is consistent with naphthalene inhibiting specifically at the level of ubiquinone (coenzyme Q), an essential component of the mitochondrial electron chain. This paper demonstrates an interaction of naphthalene with Q/sub 10/, the most common form of ubiquinone in mammalian heart mitochondria, that may be responsible for naphthalene's observed inhibitory effect.
- Research Organization:
- Oklahoma State Univ., Stillwater
- OSTI ID:
- 5213420
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 31:6; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550500 -- Metabolism
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BENZOQUINONES
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CELL CULTURES
CHEMISTRY
COENZYMES
CONDENSED AROMATICS
ENERGY SOURCES
FOSSIL FUELS
FUELS
HEART
HYDROCARBONS
INHIBITION
KINETICS
MITOCHONDRIA
NAPHTHALENE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
PETROLEUM
QUINONES
REACTION KINETICS
RESPIRATION
SPECTRA
UBIQUINONE
ULTRAVIOLET SPECTRA
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BENZOQUINONES
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CELL CULTURES
CHEMISTRY
COENZYMES
CONDENSED AROMATICS
ENERGY SOURCES
FOSSIL FUELS
FUELS
HEART
HYDROCARBONS
INHIBITION
KINETICS
MITOCHONDRIA
NAPHTHALENE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
PETROLEUM
QUINONES
REACTION KINETICS
RESPIRATION
SPECTRA
UBIQUINONE
ULTRAVIOLET SPECTRA