Anti-idiotypes against a monoclonal anti-haloperidol antibody bind to dopamine receptor

Journal Article · Thu Dec 31 23:00:00 EST 1987 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90498-5· OSTI ID:5210145

Elazar, Z; Kanety, H; Schreiber, M; Fuchs, S

Anti-idiotypic antibodies were raised in rabbits by immunization with a monoclonal anti-haloperidol antibody. Some of these anti-idiotypic antibodies bind in a concentration dependent manner to bovine striatal membranes. Following affinity purification, these antibodies inhibit haloperidol binding to striatal membranes and deplete (/sup 3/H)-spiperone binding sites from a solubilized preparation of striatal membranes. It is thus concluded that these anti-idiotypic antibodies are an internal image of haloperidol and as such can interact with D/sub 2/-dopamine receptors.

• Research Organization: Weizmann Institute of Science, Rehovot (Israel)
• OSTI ID: 5210145
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 42:20; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
ANTIBODIES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CELL MEMBRANES
DOPAMINE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
MONOCLONAL ANTIBODIES
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PROTEINS
RABBITS
REACTION KINETICS
RECEPTORS
SPIPERONE
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES