Distinct development patterns of c-mos protooncogene expression in female and male mouse germ cells
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
The protooncogene c-mos is expressed in murine reproductive tissues, producing transcripts of 1.7 and 1.4 kilobases in testis and ovary, respectively. In situ hybridization analysis of c-mos expression in histological sections of mouse ovaries revealed that oocytes are the predominant if not exclusive source of c-mos transcripts. /sup 35/S- or /sup 32/P-labelled RNA probes were transcribed. c-mos transcripts accumulate in growing oocytes, increasing 40- to 90-fold during oocyte and follicular development. c-mos transcripts were also detected in male germ cells and are most abundant after the cells have entered the haploid stage of spermatogenesis. This developmentally regulated pattern of c-mos expression in oocytes and spermatogenic cells suggest that the c-mos gene product may have a function in normal germ-cell differentiation or early embryogenesis.
- Research Organization:
- Columbia Univ. College of Physicians and Surgeons, New York, NY (USA)
- OSTI ID:
- 5208258
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:15; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
EVEN-ODD NUCLEI
FEMALE GENITALS
GENE REGULATION
GENES
GERM CELLS
GLANDS
GONADS
HYBRIDIZATION
ISOTOPES
LIGHT NUCLEI
LIVER
MALE GENITALS
MAMMALS
MESSENGER-RNA
MICE
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ONCOGENES
ORGANIC COMPOUNDS
ORGANS
OVARIES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIOISOTOPES
RNA
RODENTS
SULFUR 35
SULFUR ISOTOPES
TESTES
VERTEBRATES
550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
EVEN-ODD NUCLEI
FEMALE GENITALS
GENE REGULATION
GENES
GERM CELLS
GLANDS
GONADS
HYBRIDIZATION
ISOTOPES
LIGHT NUCLEI
LIVER
MALE GENITALS
MAMMALS
MESSENGER-RNA
MICE
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ONCOGENES
ORGANIC COMPOUNDS
ORGANS
OVARIES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIOISOTOPES
RNA
RODENTS
SULFUR 35
SULFUR ISOTOPES
TESTES
VERTEBRATES