Health effects of combustion-generated soot and polycyclic aromatic hydrocarbons. Progress report, May 1, 1981-April 30, 1982

Technical Report · Mon Nov 30 23:00:00 EST 1981

OSTI ID:5206601

Thilly, W; Wogan, G N

Progress in the following subject areas is reported on: (1) development and application of a mutation assay with human lymphoblasts competent in xenobiotic metabolism; (2) development of facile human cell mutation assay using phagocytosis of microspheres; (3) internal standards for survival to increase the accuracy of single cell mutation assays; and (4) studies of biological mechanisms of mutation by major soot mutagens and related compounds (fluoranthene, alkyl phenanthrenes, benzocinnolines and nitropyrenes). (ACR)

• Research Organization: Massachusetts Inst. of Tech., Cambridge (USA)
• DOE Contract Number: AS02-77EV04267
• OSTI ID: 5206601
• Report Number(s): DOE/EV/04267-5; ON: DE82009814
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
ANIMAL CELLS
ANIMALS
AROMATICS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CULTURES
COMBUSTION PRODUCTS
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
DNA
HYDROCARBONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
METABOLISM
MICROSPHERES
MUTAGENESIS
MUTAGENS
MUTATIONS
NITROGEN COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHAGOCYTOSIS
PHENANTHRENE
POLYCYCLIC AROMATIC HYDROCARBONS
PRIMATES
PYRENE
RESEARCH PROGRAMS
SOMATIC CELLS
SOOT
VERTEBRATES