health effects of dielectric gases: preliminary report
Technical Report
·
OSTI ID:5206567
The toxicity of various dielectric gases was assayed in two in vitro systems: Chinese hamster V79 (lung) cells (mammalian) and yeast (Saccharomyces cerevisiae). Exposures were carried out in small tubes which were constantly rotated, so that cells were exposed to the gas with only a thin layer of cell culture liquid covering them. Results indicate that SF/sub 6/ is essentially without cytotoxic effect on both systems. After discharge of 16 kJ total spark energy in 60 cm/sup 3/ of SF/sub 6/, the sparked samples were found to be cytotoxic to the mammalian cells, but not to the yeast. The toxicity of these sparked samples to the mammalian system was observed within 15 min of exposure of the cells and the degree of toxicity increased with time of exposure. In addition, increasing spark energy produced samples with increased cytotoxic activity. Yeast cells were unresponsive to octafluorocyclobutane (c-C/sub 4/F/sub 8/) and sparked SF/sub 6/. However, as little as 10% perfluoro-2-butyne (PFB) resulted in 100% toxic response to the yeast, and 95% hexafluorocyclobutene (c-C/sub 4/F/sub 6/) prevented their normal exponential growth, but did not result in mortality.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5206567
- Report Number(s):
- ORNL/TM-8353; ON: DE82019724
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKENES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CELL CULTURES
CLONE CELLS
CYCLOALKENES
DATA
DIELECTRIC MATERIALS
EXPERIMENTAL DATA
FLUIDS
FLUORIDES
FLUORINE COMPOUNDS
FUNGI
GASES
GROWTH
HALIDES
HALOGEN COMPOUNDS
HAMSTERS
HYDROCARBONS
INFORMATION
MAMMALS
MATERIALS
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
PLANTS
RESEARCH PROGRAMS
RESPIRATORY TRACT CELLS
RODENTS
SULFUR COMPOUNDS
SULFUR FLUORIDES
TOXICITY
VERTEBRATES
YEASTS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKENES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CELL CULTURES
CLONE CELLS
CYCLOALKENES
DATA
DIELECTRIC MATERIALS
EXPERIMENTAL DATA
FLUIDS
FLUORIDES
FLUORINE COMPOUNDS
FUNGI
GASES
GROWTH
HALIDES
HALOGEN COMPOUNDS
HAMSTERS
HYDROCARBONS
INFORMATION
MAMMALS
MATERIALS
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
PLANTS
RESEARCH PROGRAMS
RESPIRATORY TRACT CELLS
RODENTS
SULFUR COMPOUNDS
SULFUR FLUORIDES
TOXICITY
VERTEBRATES
YEASTS