High yield synthesis of 6-(18F)fluoro-L-dopa
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5205942
The radiofluorination of L-dopa with (/sup 18/F)F2 was investigated with the purpose of improving the yield of 6-(/sup 18/F)fluoro-L-dopa. When boron trifluoride was added to the reaction mixture in hydrogen fluoride (HF), the yield was increased threefold. Nine millicuries of 6-(/sup 18/F)fluoro-L-dopa were produced from 100 mCi (/sup 18/F)F2 routinely and reliably after 2 hr of preparation. If acetonitrile or water were substituted for HF, little or no 6-fluoro-L-dopa was made.
- Research Organization:
- McMaster Univ. Medical Centre, Hamilton, Ontario
- OSTI ID:
- 5205942
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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Aromatic radiofluorination with (/sup 18/F)fluorine gas: 6-(/sup 18/F)fluoro-L-dopa
Journal Article
·
Mon Dec 01 00:00:00 EST 1986
· J. Nucl. Med.; (United States)
·
OSTI ID:5205942
One-pot synthesis of high molar activity 6-[18F]fluoro-l-DOPA by Cu-mediated fluorination of a BPin precursor
Journal Article
·
Tue Sep 17 00:00:00 EDT 2019
· Organic and Biomolecular Chemistry
·
OSTI ID:5205942
+7 more
Aromatic radiofluorination with (/sup 18/F)fluorine gas: 6-(/sup 18/F)fluoro-L-dopa
Journal Article
·
Thu Nov 01 00:00:00 EST 1984
· J. Nucl. Med.; (United States)
·
OSTI ID:5205942
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
DOPA
FLUORINATION
LABELLING
ARSENIC
BORANES
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
FLUORINE 18
LABELLED COMPOUNDS
SILANES
AMINO ACIDS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BORON COMPOUNDS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DRUGS
ELEMENTS
FLUORINE ISOTOPES
HALOGENATION
HOURS LIVING RADIOISOTOPES
HYDRIDES
HYDROGEN COMPOUNDS
HYDROXY ACIDS
ISOTOPES
LIGHT NUCLEI
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SILICON COMPOUNDS
RADIOISOTOPES
SEMIMETALS
SILICON COMPOUNDS
SYNTHESIS
YIELDS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
DOPA
FLUORINATION
LABELLING
ARSENIC
BORANES
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
FLUORINE 18
LABELLED COMPOUNDS
SILANES
AMINO ACIDS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BORON COMPOUNDS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DRUGS
ELEMENTS
FLUORINE ISOTOPES
HALOGENATION
HOURS LIVING RADIOISOTOPES
HYDRIDES
HYDROGEN COMPOUNDS
HYDROXY ACIDS
ISOTOPES
LIGHT NUCLEI
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SILICON COMPOUNDS
RADIOISOTOPES
SEMIMETALS
SILICON COMPOUNDS
SYNTHESIS
YIELDS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials