Formation of self-assembled monolayers by chemisorption of derivatives of oligo(ethylene glycol) of structure HS(CH sub 2 ) sub 11 (OCH sub 2 CH sub 2 ) sub m OH on gold

Journal Article · Wed Jan 02 04:00:00 EST 1991 · Journal of the American Chemical Society; (United States)

DOI:https://doi.org/10.1021/ja00001a002· OSTI ID:5201504

Pale-Grosdemange, C; Simon, E S; Prime, K L; Whitesides, G M ^[1]

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1. Harvard Univ., Cambridge, MA (USA)

This paper describes the preparation of oligo(ethylene glycol)-terminated alkanethiols having structure HS-(CH{sub 2}){sub 11}(OCH{sub 2}CH{sub 2}){sub m}OH (m = 3-7) and their use in the formation of self-assembled monolayers (SAMs) on gold. A combination of experimental evidence derived from x-ray photoelectron spectroscopy (XPS), measurement of contact angles, and ellipsometry implies substantial disorder in the oligo(ethylene glycol)-containing segment. The order in the {minus}(CH{sub 2}){sub 11}-group is not defined by the available evidence. The SAMSs are moderately hydrophilic: {theta}{sub a}(H{sub 2}O) = 34-38; {theta}{sub r}(H{sub 2}O) = 22-25. A study of monolayers containing mixtures of HS(CH{sub 2}){sub 11}CH{sub 3} and HS(CH{sub 2}){sub 11}(OCH{sub 2}CH{sub 2}){sub 6}OH suggest that the oligo(ethylene glycol) moieties are effective at preventing underlying methylene groups from influencing wetting by water. A limited study demonstrates that these oligo(ethylene glycol)-containing SAMs resist the adsorption of protein from solution and suggests that SAMs will be a useful model system for studying the adsorption of proteins onto organic surfaces.

• OSTI ID: 5201504
• Journal Information: Journal of the American Chemical Society; (United States), Journal Name: Journal of the American Chemical Society; (United States) Vol. 113:1; ISSN 0002-7863; ISSN JACSA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201* -- Chemical & Physicochemical Properties
ALCOHOLS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
CHEMISORPTION
DATA
ELECTRON SPECTROSCOPY
ELEMENTS
ELLIPSOMETRY
EXPERIMENTAL DATA
GLYCOLS
GOLD
HYDROXY COMPOUNDS
INFORMATION
MEASURING METHODS
METALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHOTOELECTRON SPECTROSCOPY
SEPARATION PROCESSES
SORPTION
SPECTROSCOPY
SYNTHESIS
THIOLS
TRANSITION ELEMENTS