Bone and mineral metabolism in adult celiac disease

Journal Article · Tue Mar 01 00:00:00 EST 1988 · Am. J. Gastroenterol.; (United States)

OSTI ID:5201253

Caraceni, M P; Molteni, N; Bardella, M T; Ortolani, S; Nogara, A; Bianchi, P A

Bone mineral density (/sup 125/I photon absorptiometry) was lower in 20 untreated adult celiac patients than in sex- and age-matched controls (p less than 0.001), and plasma alkaline phosphatase, parathyroid hormone, urinary hydroxyproline/creatinine levels were higher than normal (p less than 0.05, less than 0.001, less than 0.05, respectively). Gluten-free diet was started, and the patients were divided randomly into two treatment groups, one which received oral 25-hydroxyvitamin D 50 micrograms/day and one which did not. After 12 months' treatment, bone turnover markers showed a decrease, which did not reach statistical significance, and bone mineral density did not show significant modifications compared with base line in either group. It was found that a gluten-free diet followed for 1 yr can prevent further bone loss, but no significant differences were detected between the two groups.

• Research Organization: Univ. di Milano (Italy)
• OSTI ID: 5201253
• Journal Information: Am. J. Gastroenterol.; (United States), Vol. 83:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
MINERALS
METABOLISM
SKELETAL DISEASES
PATHOGENESIS
ADULTS
ALKALINE PHOSPHATASE
CREATININE
ERGOCALCIFEROL
HYDROXYPROLINE
IODINE 125
PARATHORMONE
PATIENTS
SKELETON
TRACER TECHNIQUES
AGE GROUPS
AMINES
AMINO ACIDS
AZOLES
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
ESTERASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROLASES
HYDROXY ACIDS
IMIDAZOLES
IMINES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHOSPHATASES
PYRROLES
PYRROLIDINES
RADIOISOTOPES
VITAMIN D
VITAMINS
550901* - Pathology- Tracer Techniques