Characterization of prostate cancer, benign prostatic hyperplasia and normal prostates using transrectal 31phosphorus magnetic resonance spectroscopy: a preliminary report

Journal Article · Mon Jul 01 00:00:00 EDT 1991 · Journal of Urology; (United States)

OSTI ID:5200655

Narayan, P; Jajodia, P; Kurhanewicz, J; Thomas, A; MacDonald, J; Hubesch, B; Hedgcock, M; Anderson, C M; James, T L; Tanagho, E A ^[1]

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1. Univ. of California School of Medicine, San Francisco (USA)

We assessed the ability of 31phosphorus (31P) transrectal magnetic resonance spectroscopy to characterize normal human prostates as well as prostates with benign and malignant neoplasms. With a transrectal probe that we devised for surface coil spectroscopy we studied 15 individuals with normal (5), benign hyperplastic (4) and malignant (6) prostates. Digital rectal examination, transrectal ultrasonography and magnetic resonance imaging were used to aid in accurate positioning of the transrectal probe against the region of interest within the prostate. The major findings of the in vivo studies were that normal prostates had phosphocreatine-to-adenosine triphosphate (ATP) ratios of 1.2 +/- 0.2, phosphomonoester-to-beta-ATP ratios of 1.1 +/- 0.1 and phosphomonoester-to-phosphocreatine ratios of 0.9 +/- 0.1. Malignant prostates had phosphocreatine-to-beta-ATP ratios that were lower (0.7 +/- 0.1) than those of normal prostates (p less than 0.02) or prostates with benign hyperplasia. Malignant prostates had phosphomonoester-to-beta-ATP ratios (1.8 +/- 0.2) that were higher than that of normal prostates (p less than 0.02). Using the phosphomonoester-to-phosphocreatine ratio, it was possible to differentiate metabolically malignant (2.7 +/- 0.3) from normal prostates (p less than 0.001), with no overlap of individual ratios. The mean phosphomonoester-to-phosphocreatine ratio (1.5 +/- 0.5) of prostates with benign hyperplasia was midway between the normal and malignant ratios, and there was overlap between individual phosphomonoester-to-phosphocreatine ratios of benign prostatic hyperplasia glands with that of normal and malignant glands. To verify the in vivo results, we performed high resolution magnetic resonance spectroscopy on perchloric acid extracts of benign prostatic hyperplasia tissue obtained at operation and on a human prostatic cancer cell line DU145.

• OSTI ID: 5200655
• Journal Information: Journal of Urology; (United States), Vol. 146:1; ISSN 0022-5347
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
NEOPLASMS
DIAGNOSIS
PROSTATE
ATP
MAN
NUCLEAR MAGNETIC RESONANCE
PHOSPHORUS 31
RECTUM
TRACER TECHNIQUES
ULTRASONOGRAPHY
ANIMALS
BODY
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
GLANDS
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
LARGE INTESTINE
LIGHT NUCLEI
MAGNETIC RESONANCE
MALE GENITALS
MAMMALS
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS ISOTOPES
PRIMATES
RESONANCE
STABLE ISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics