Synthesis of (2-11C)5,5-dimethyl-2,4-oxazolidinedione for studies with positron tomography
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5192086
We have developed a method for the synthesis of (2-11C)5,5-dimethyl-2,4-oxazolidinedione ((2-11C)DMO) for use with positron emission tomography to measure regional tissue pH in vivo in man. (2-11C)Dimethyl carbonate (DMC) was prepared from (C-11)phosgene and excess of sodium methoxide in methanol containing dimethyl carbonate as added carrier. The (2-11C)DMC solution was then reacted with 2-hydroxyisobutyramide at 150 degrees C for 10 min to yield, after HPLC separation, (2-11C)DMO with a radiochemical yield of 20-56%. Chemical yields were 78-92%, and specific activity ranged as high as 830 mCi/millimol.
- Research Organization:
- Laboratory of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
- OSTI ID:
- 5192086
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:3; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Tautomerism in the series of methyl 5,5-dimethyl-2,4-dioxohexanoate acylhydrazones
11C-Iodoantipyrine for the measurement of regional cerebral blood flow by positron emission tomography. Validation studies
Synthesis of 3-(C-11-methyl)-nifedipine, a potent Ca/sup ++/ channel antagonist, for positron emission tomography
Journal Article
·
Thu Jul 10 00:00:00 EDT 1986
· J. Org. Chem. USSR (Engl. Transl.); (United States)
·
OSTI ID:6136867
11C-Iodoantipyrine for the measurement of regional cerebral blood flow by positron emission tomography. Validation studies
Journal Article
·
· Stroke; (United States)
·
OSTI ID:5549980
Synthesis of 3-(C-11-methyl)-nifedipine, a potent Ca/sup ++/ channel antagonist, for positron emission tomography
Conference
·
Sat Dec 31 23:00:00 EST 1983
· J. Nucl. Med.; (United States)
·
OSTI ID:6842988
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON COMPOUNDS
CARBON ISOTOPES
CARBONATES
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
CHROMATOGRAPHY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIQUID COLUMN CHROMATOGRAPHY
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXAZOLES
OXYGEN COMPOUNDS
PH VALUE
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
SYNTHESIS
TOMOGRAPHY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON COMPOUNDS
CARBON ISOTOPES
CARBONATES
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
CHROMATOGRAPHY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIQUID COLUMN CHROMATOGRAPHY
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXAZOLES
OXYGEN COMPOUNDS
PH VALUE
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
SYNTHESIS
TOMOGRAPHY