The excitatory amino acid receptor antagonist MK-801 prevents the hypersensitivity induced by spinal cord ischemia in the rat

Journal Article · Thu Aug 01 04:00:00 EDT 1991 · Experimental Neurology; (United States)

DOI:https://doi.org/10.1016/0014-4886(91)90174-B· OSTI ID:5191078

Hao, J X; Xu, X J; Aldskogius, H; Seiger, A; Wiesenfeld-Hallin, Z ^[1]

---

1. Karolinska Institute, Huddinge University Hospital (Sweden)

Protection by the NMDA receptor antagonist MK-801 against transient spinal cord ischemia-induced hypersensitivity was studied in rats. The spinal ischemia was initiated by vascular occlusion resulting from the interaction between the photosensitizing dye Erythrosin B and an argon laser beam. The hypersensitivity, termed allodynia, where the animals reacted by vocalization to nonnoxious mechanical stimuli in the flank area, was consistently observed during several days after induction of the ischemia. Pretreatment with MK-801 (0.1-0.5 mg/kg, iv) 10 min before laser irradiation dose dependently prevented the occurrence of allodynia. The neuroprotective effect of MK-801 was not reduced by maintaining normal body temperature during and after irradiation. There was a significant negative correlation between the delay in the administration of MK-801 after irradiation and the protective effect of the drug. Histological examination revealed slight morphological damage in the spinal cord in 38% of control rats after 1 min of laser irradiation without pretreatment with MK-801. No morphological abnormalities were observed in rats after pretreatment with MK-801 (0.5 mg/kg). The present results provide further evidence for the involvement of excitatory amino acids, through activation of the NMDA receptor, in the development of dysfunction following ischemic trauma to the spinal cord.

• OSTI ID: 5191078
• Journal Information: Experimental Neurology; (United States), Journal Name: Experimental Neurology; (United States) Vol. 113:2; ISSN 0014-4886; ISSN EXNEA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
560400 -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANEMIAS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ENZYME INHIBITORS
HEMIC DISEASES
ISCHEMIA
ISOTOPE APPLICATIONS
KINETICS
LASER RADIATION
MAMMALS
MORPHOLOGICAL CHANGES
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PAIN
RADIATIONS
RATS
REACTION KINETICS
RODENTS
SPINAL CORD
SYMPTOMS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES