Mutagenic activation of 2-aminofluorene by fluorescent light

Journal Article · Mon Dec 31 23:00:00 EST 1984 · Teratog., Carcinog., Mutagen.; (United States)

DOI:https://doi.org/10.1002/tcm.1770050108· OSTI ID:5186182

White, G L; Heflich, R H

To determine the effect of artificially produced light on the direct mutagenicity of 2-aminofluorene, that arylamine was irradiated with either sun, cool-white, black, blue, or yellow fluorescent light or held in the dark prior to assaying for mutagenicity using Salmonella typhimurium strain TA98. The order of effectiveness of these exposures in potentiating the mutagenicity of 2-aminofluorene was sun greater than black greater than cool-white greater than blue greater than yellow approximately equal to dark. By varying the radiant flux densities produced by the lamps and using optical filters, wavelengths of light up to approximately 450 nm were found to be effective in the mutagenic potentiation. Studies using radical scavengers and oxygen modifiers indicated that the light-induced mutagenicity was dependent on oxygen and that singlet oxygen may be an effective activator of 2-aminofluorene. The mutagenicity of fluorene was not increased by exposure to light, while only sunlight potentiated the mutagenicity of 2-acetylaminofluorene. This result suggested the importance of the primary amine in the mutagenic activation of 2-aminofluorene by light. These studies indicate that the effect of light on environmental contaminants must be considered in assessing their genotoxic potential.

• Research Organization: National Center for Toxicological Research, Jefferson, AR
• OSTI ID: 5186182
• Journal Information: Teratog., Carcinog., Mutagen.; (United States), Journal Name: Teratog., Carcinog., Mutagen.; (United States) Vol. 1; ISSN TCMUD
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400500* -- Photochemistry
AMINES
AROMATICS
BACTERIA
CHEMICAL ACTIVATION
CHEMISTRY
CONDENSED AROMATICS
ELEMENTS
FLUORESCENCE
FLUX DENSITY
HYDROCARBONS
LUMINESCENCE
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
MUTAGENS
NONMETALS
ORGANIC COMPOUNDS
OXYGEN
PHOTOCHEMISTRY
RADIANT FLUX DENSITY
RADIATIONS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SOLAR RADIATION
STELLAR RADIATION