Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q

Journal Article · Sat Feb 01 00:00:00 EST 1997 · American Journal of Human Genetics

OSTI ID:518508

Wirtz, M K; Samples, J R; Kramer, P L ^[1]

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1. Oregon Health Sciences Univ., Portland, OR (United States); and others

Glaucoma is the third-leading cause of blindness in the world, affecting >13.5 million people. Adult-on-set primary open-angle glaucoma (POAG) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal dominant trait. Twelve affected family members were identified from 44 at-risk individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis of recombinant haplotypes suggesting a total inclusion region of 11.1 cM between markers D3S3637 and D3S1744. This is the first report of mapping of an adult-onset POAG gene to chromosome 3q, gene symbol GLC1C. 57 refs., 3 figs., 3 tabs.

• OSTI ID: 518508
• Journal Information: American Journal of Human Genetics, Vol. 60, Issue 2; Other Information: PBD: Feb 1997
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOME 3
GENETIC MAPPING
GENES
GENE MUTATIONS
GENE RECOMBINATION
F CODES
SENSE ORGANS DISEASES
AGE DEPENDENCE
GENETICS
PATIENTS
DOMINANT MUTATIONS
BIOLOGICAL MARKERS
STATISTICS