Studies on the mechanism of benzene toxicity

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Environmental Health Perspectives; (USA)

DOI:https://doi.org/10.1289/ehp.898231· OSTI ID:5181984

Snyder, R; Dimitriadis, E; Guy, R; Hu, P; Cooper, K; Bauer, H; Witz, G; Goldstein, B D ^[1]

---

1. Rutgers, State Univ. of New Jersey, Piscataway (USA)

Using the 59Fe uptake method of Lee et al. it was shown that erythropoiesis in female mice was inhibited following IP administration of benzene, hydroquinone, p-benzoquinone, and muconaldehyde. Toluene protected against the effects of benzene. Coadministration of phenol plus either hydroquinone or catechol resulted in greatly increased toxicity. The combination of metabolites most effective in reducing iron uptake was hydroquinone plus muconaldehyde. We have also shown that treating animals with benzene leads to the formation of adducts of bone marrow DNA as measured by the 32P-postlabeling technique.

• OSTI ID: 5181984
• Journal Information: Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 82; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
ALKYLATED AROMATICS
ANIMAL TISSUES
ANIMALS
AROMATICS
BENZENE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
DAYS LIVING RADIOISOTOPES
DNA ADDUCTS
ERYTHROPOIESIS
EVEN-ODD NUCLEI
HEMATOPOIETIC SYSTEM
HYDROCARBONS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
METABOLITES
MICE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHENOLS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
QUINONES
RADIOISOTOPES
RATS
RODENTS
SYNERGISM
TISSUES
TOLUENE
TOXICITY
TRACER TECHNIQUES
VERTEBRATES