Quantitative trait loci for murine growth

Journal Article · Mon Apr 01 04:00:00 EST 1996 · Genetics

OSTI ID:518190

Cheverud, J M; Swinderen, B van; Cothran, K; Perel, C ^[1]

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1. Washington Univ. School of Medicine, St Louis, MO (United States); and others

Body size is an archetypal quantitative trait with variation due to the segregation of many gene loci, each of relatively minor effect, and the environment. We examine the effects of quantitative trait loci (QTLs) on age-specific body weights and growth in the F{sub 2} intercross of the LG/J and SM/J strains of inbred mice. Weekly weights (1-10 wk) and 75 microsatellite genotypes were obtained for 535 mice. Interval mapping was used to locate and measure the genotypic effects of QTLs on body weight and growth. QTL effects were detected on 16 of the 19 autosomes with several chromosomes carrying more than one QTL. The number of QTLs for age-specific weights varied from seven at 1 week to 17 at 10 wk. The QTLs were each of relatively minor, subequal effect. QTLs affecting early and late growth were generally distinct, mapping to different chromosomal locations indicating separate genetic and physiological systems for early and later murine growth. 50 refs., 2 figs., 5 tabs.

• OSTI ID: 518190
• Journal Information: Genetics, Journal Name: Genetics Journal Issue: 4 Vol. 142; ISSN GENTAE; ISSN 0016-6731
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AGE DEPENDENCE
BIOLOGICAL MARKERS
CHROMOSOMES
GENES
GENETIC MAPPING
GENOTYPE
GROWTH
HYBRIDIZATION
MICE
STATISTICS
WEIGHT