Transmission-ratio distortion through F{sub 1} females at chromosome 11 loci linked to Om in the mouse DDK syndrome
- Temple Univ. School of Medicine, Philadelphia, PA (United States); and others
We determined the genotypes of >200 offspring that are survivors of matings between female reciprocal F{sub 1} hybrids (between the DDK and C57BL/6J inbred mouse strains) and C57BL/6J males at markers linked to the Ovum mutant (Om) locus on chromosome 11. In contrast to the expectations of our previous genetic model to explain the {open_quotes}DDK syndrome,{close_quotes} the genotypes of these offspring do not reflect preferential survival of individuals that receive C57BL/6J alleles from the F{sub 1} females in the region of chromosome 11 to which the Om locus has been mapped. In face, we observe significant transmission-ratio distortion in favor of DDK alleles in this region. These results are also in contrast to the expectation of Wakasugi`s genetic model for the inheritance of Om, in which he proposed equal transmission of DDK and non-DDK alleles from F{sub 1} females. We propose that the results of these experiments may be explained by reduced expression of the maternal DDK Om allele or expression of the maternal DDK Om allele in only a portion of the ova of F{sub 1} females. 23 refs., 2 figs., 2 tabs.
- OSTI ID:
- 518189
- Journal Information:
- Genetics, Vol. 142, Issue 4; Other Information: PBD: Apr 1996
- Country of Publication:
- United States
- Language:
- English
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